| Title | [When do combinations of diuretics make sense?] | | Author(s) | Fuster D | | Institution | Universitätsklinik für Nephrologie und Hypertonie, Inselspital, Bern. | | Source | Ther Umsch 2009 Nov; 66(11):725-729. | | Abstract | Diuretics are commonly prescribed by physicians to contract the ECF volume. In two clinical situations combining different classes of diuretics make sense: First, if a loop diuretic at maximal dose alone does not lead to sufficient diuresis or second, if the side effect of a diuretic needs to be corrected by adding a diuretic of another class. The latter is clinically often used to counteract loop or thiazide diuretic-induced hypokalemia by the addition of a potassium sparing diuretic. Key to a reasonable combination of diuretics is understanding of the pharmaco-kinetics and knowledge of the molecular targets of the diuretics involved. | | Language | GER | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19885788 |
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